Observations on the Pathophysiology and Mechanisms for Cyclic Neutropenia
نویسندگان
چکیده
منابع مشابه
Observations on the Pathophysiology and Mechanisms for Cyclic Neutropenia
We review the basic pathology of cyclical neutropenia in both humans and the grey collie, and examine the role that mathematical modeling of hematopoietic cell production has played in our understanding of the origins of this fascinating dynamical disease.
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Cyclic neutropenia (CN) has been well documented in humans and the gray collie. A recent model of the architecture and dynamics of hematopoiesis has been used to provide insights into the mechanism of cycling of this disorder. It provides a link between the cycling period and the cells where the mutated ELA2 is expressed. Assuming that the biologic defect in CN is the same in dogs, and the obse...
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ژورنال
عنوان ژورنال: Mathematical Modelling of Natural Phenomena
سال: 2006
ISSN: 0973-5348
DOI: 10.1051/mmnp:2008004